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Tocris/SL 327/1969/50/50 mg

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货号: 1969/50

品牌: Tocris

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Description: Selective inhibitor of MEK1 and MEK2; brain penetrant

Chemical Name: α-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Selective inhibitor of MEK1 and MEK2 (IC₅₀ values are 0.18 and 0.22 μM respectively); blocks hippocampal LTP in vitro. Brain penetrant in vivo, blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration.

Compound Libraries

SL 327 is also offered as part of the Tocriscreen Epigenetics Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	335.35
Formula	C₁₆H₁₂F₃N₃S
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	305350-87-2
PubChem ID	9549284
InChI Key	JLOXTZFYJNCPIS-FYWRMAATSA-N
Smiles	NC(SC1=CC=C(N)C=C1)=C(C#N)C1=CC=CC=C1C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	33.53	100
	ethanol	16.77	50

Preparing Stock Solutions

The following data is based on the product molecular weight 335.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.98 mL	14.91 mL	29.82 mL
5 mM	0.6 mL	2.98 mL	5.96 mL
10 mM	0.3 mL	1.49 mL	2.98 mL
50 mM	0.06 mL	0.3 mL	0.6 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Davis et al (2000) The MAPK/ERK cascade targets both Elk-1 and cAMP response element-binding protein to control long-term potentiation-dependent gene expression in the dentate gyrus in vivo. J.Neurosci. 20 4563 PMID: 10844026

Scherle et al (2000) Regulation of cyclooxygenase-2 induction in the mouse uterus during decidualization. An event of early pregnancy. J.Biol.Chem. 275 37086 PMID: 10969080

Wang et al (2003) Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis. J.Pharmacol.Exp.Ther. 304 172 PMID: 12490588

Atkins et al (1998) The MAPK cascade is required for mammalian associative learning. Nature Neurosci. 1 602 PMID:

Keywords: SL 327, supplier, Selective, inhibitors, inhibits, MEK1, MEK2, brain, penetrant, Mitogen-Activated, Protein, Kinase, MEK, Kinases, SL327, MEK, MEK, Tocris Bioscience

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