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Tocris/Simvastatin/1965/50/50 mg

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货号: 1965/50

品牌: Tocris

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Description: HMG-CoA reductase inhibitor

Chemical Name: (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyly-2,2-dimethyl butanoate

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

HMG-CoA reductase inhibitor; decreases levels of low density lipoprotein. Has multiple biological effects including bone formation stimulation, inhibition of smooth muscle cell proliferation and migration, induction of ferroptosis, and anticancer and anti-inflammatory activity. Inactive lactone prodrug of simvastatin hydroxy acid, naturally bioactivated in vivo following oral administration.

Compound Libraries

Simvastatin is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	418.57
Formula	C₂₅H₃₈O₅
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	79902-63-9
PubChem ID	54454
InChI Key	RYMZZMVNJRMUDD-HGQWONQESA-N
Smiles	[H][C@@]12C(C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(O3)=O)=C[C@H](C)C[C@@H]1OC(C(C)(C)CC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	20.93	50
	ethanol	31.39	75

Preparing Stock Solutions

The following data is based on the product molecular weight 418.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.39 mL	11.95 mL	23.89 mL
5 mM	0.48 mL	2.39 mL	4.78 mL
10 mM	0.24 mL	1.19 mL	2.39 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Garrett et al (2001) Statins and bone formation. Curr.Pharm.Des. 7 715 PMID: 11405194

Kaushal et al (2003) Potential anticancer effects of statins: fact or fiction? Endothelium 10 49 PMID: 12699077

White (1999) Pharmacological effects of HMG CoA reductase inhibitors other than lipoprotein modulation. J.Clin.Pharmacol. 39 111 PMID: 11563401

Reinoso et al (2002) Preclinical pharmacokinetics of statins. Methods Find.Exp.Clin.Pharmacol. 24 593 PMID: 12616706

Keywords: Simvastatin, supplier, HMG-CoA, reductase, inhibitors, inhibits, Reductases, ferroptosis, hyperlipidemia, hypolipemic, HMG-CoA, Reductase, Ferroptosis, HMG-CoA, Reductase, Tocris Bioscience

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