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Tocris/SB 334867/1960/10/10 mg

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货号: 1960/10

品牌: Tocris

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Description: Selective non-peptide OX₁ antagonist

Chemical Name: N-(2-Methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl urea

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Selective non-peptide orexin OX₁ receptor antagonist. pK_b values are 7.2 and < 5 for inhibition of intracellular Ca²⁺ release in CHO cells expressing human OX₁ and OX₂ receptors respectively. Blocks orexin-A induced grooming and feeding following systemic administration in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Compound Libraries

SB 334867 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	319.32
Formula	C₁₇H₁₃N₅O₂
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	792173-99-0
PubChem ID	6604926
InChI Key	AKMNUCBQGHFICM-UHFFFAOYSA-N
Smiles	CC1=NC2=CC=C(NC(=O)NC3=CC=NC4=CC=CN=C34)C=C2O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	31.93	100mM with gentle warming
	ethanol	3.19	10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 319.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.13 mL	15.66 mL	31.32 mL
5 mM	0.63 mL	3.13 mL	6.26 mL
10 mM	0.31 mL	1.57 mL	3.13 mL
50 mM	0.06 mL	0.31 mL	0.63 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Duxon et al (2001) Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX₁) receptors, with downstream 5-HT_2C receptor involvement. Psychopharmacology 153 203 PMID: 11205420

Haynes et al (2000) A selective orexin-1 receptor antagonist reduces food consumption in male and female rats. Regul.Pept. 96 45 PMID: 11102651

Porter et al (2001) 1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor. Bioorg.Med.Chem.Lett. 11 1907 PMID: 11459658

Smart et al (2001) SB-334867-A: the first selective orexin-1 receptor antagonist. Br.J.Pharmacol. 132 1179 PMID: 11250867

Keywords: SB 334867, supplier, Selective, non-peptide, OX1, antagonists, Orexin1, Receptors, SB334867, GlaxoSmithKline, GSK, OX1, Receptor, OX1, Receptor, Tocris Bioscience

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