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Tocris/U 46619/1932/1/1 mg

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货号: 1932/1

品牌: Tocris

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Description: Potent, stable thromboxane A₂ (TP) receptor agonist

Alternative Names: 9,11-Dideoxy-9a,11a-methanoepoxy prostaglandin F_2a

Chemical Name: (5Z)-7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-Hydroxy-1-octenyl]-2-oxabicyclo[2.2.1]hept-5-yl]-5-heptenoic acid

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

PGH₂ (TXA₂) analog that is a potent and stable thromboxane A₂ (TP) receptor agonist (EC₅₀ = 0.035 μM). Potently stimulates TP receptor-mediated, but not other prostaglandin receptor-mediated responses in various in vitro preparations. Activates ERK-1 and ERK-2 in HEK 293 cells expressing TPα and TPβ receptors.

Technical Data

M. Wt	350.5
Formula	C₂₁H₃₄O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	56985-40-1
PubChem ID	5311493
InChI Key	LQANGKSBLPMBTJ-BRSNVKEHSA-N
Smiles	O[C@@H](CCCCC)/C=C/[C@H]1[C@@H]2OC[C@@H](C2)[C@@H]1C/C=CCCCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility	Soluble in methyl acetate (supplied pre-dissolved -10mg/ml)

Solubility

Soluble in methyl acetate (supplied pre-dissolved -10mg/ml)

Preparing Stock Solutions

The following data is based on the product molecular weight 350.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.85 mL	14.27 mL	28.53 mL
5 mM	0.57 mL	2.85 mL	5.71 mL
10 mM	0.29 mL	1.43 mL	2.85 mL
50 mM	0.06 mL	0.29 mL	0.57 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Coleman et al (1981) Comparison of the actions of U-46619, a prostaglandin H₂-analogue, with those of prostaglandin H₂ and thromboxane A₂ on some isolated smooth muscle preparations. Br.J.Pharmacol. 73 773 PMID: 7248665

Morinelli et al (1987) Receptor-mediated effects of a PGH₂ analogue (U 46619) on human platelets. Am.J.Physiol. 253 H1035 PMID: 3688248

Miggin and Kinsella (2002) Regulation of extracellular signal-regulated kinase cascades by α- and β-isoforms of the human thromboxane A₂ receptor. Mol.Pharmacol. 61 817 PMID: 11901221

Keywords: U 46619, supplier, Potent, stable, thromboxane, A2, TP, receptor, agonists, TXA2, Prostanoid, prostaglandins, prostacyclins, eicosanoids, U46619, 9, 11-Dideoxy-9a, 11a-methanoepoxy, prostaglandinF2a, 9,11-Dideoxy-9a,11a-methanoepoxy, prostaglandin, F2a, Prostanoid, Receptors, Prostanoid, Receptors, Tocris Bioscience

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