Description: Inhibitor of α-MSH release; inhibits opioid effects in vivo
Alternative Names: Pro-Leu-Gly amide, MIF-I, PLG
Biological Activity
Technical Data
Datasheets
References
Biological Activity
Inhibitor of melanocyte-stimulating hormone (MSH) release. Blocks the release of α-MSH, increases brain dopamine levels and antagonizes physiological and behavioral opioid effects in vivo.
Technical Data
M. Wt
284.36
Formula
C13H24N4O3
Sequence
PLG
(Modifications: Gly-3 = C-terminal amide)
Storage
Desiccate at -20°C
CAS Number
2002-44-0
PubChem ID
92910
InChI Key
NOOJLZTTWSNHOX-UWVGGRQHSA-N
Smiles
[H]N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 284.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass
1 mg
5 mg
10 mg
1 mM
3.52 mL
17.58 mL
35.17 mL
5 mM
0.7 mL
3.52 mL
7.03 mL
10 mM
0.35 mL
1.76 mL
3.52 mL
50 mM
0.07 mL
0.35 mL
0.7 mL
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Product Datasheets
Certificate of Analysis / Product Datasheet
Safety Datasheet
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References
References are publications that support the products' biological activity.
Kavaliers and Hirst
(1986) Inhibitory influences of FMRFamide and PLG on stress-induced opioid analgesia and activity. Brain Res. 372 370 PMID: 2871903
Mishraet al (1983) Pharmacology of L-Prolyl-L-Leucyl-Glycinamide (PLG): a review. Methods Find.Exp.Clin.Pharmacol. 5 203 PMID: 6136640
Plotnikoff and Kastin
(1974) Pharmacological studies with a tripeptide, Prolyl-Leucyl Glycine amide. Arch.Int.Pharmacodyn.Ther. 211 211 PMID: 4156639
Pugsley and Lippmann
(1977) Synthetic melanocyte stimulating hormone release inhibiting factor (MIF). Part III: effect of L-prolyl-N-methyl-D-leucyl-glycinamide and MIF on biogenic amine turnover. Arzneimittelforschung 27 2293 PMID: 23796
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