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Tocris/Ro 60-0175 fumarate/1854/10/10 mg

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货号: 1854/10

品牌: Tocris

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Description: Potent, selective 5-HT_2C agonist

Chemical Name: (αS)-6-Chloro-5-fluoro-α-methyl-1H-indole-1-ethanamine fumarate

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent, selective 5-HT₂ receptor agonist; shows selectivity for the 5-HT_2C subtype (pK_i values are 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT_2C, _2A, _1A, ₆ and ₇ receptors respectively). Centrally active following oral or systemic administration in vivo.

Compound Libraries

Ro 60-0175 fumarate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	342.75
Formula	C₁₁H₁₂ClFN₂.C₄H₄O₄
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	169675-09-6
PubChem ID	6446435
InChI Key	CEPHEXXZGQBXGT-XZTIXWOLSA-N
Smiles	O=C(O)/C=C/C(O)=O.FC1=C(Cl)C=C(N(C[C@H](C)N)C=C2)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	6.86	20
	water	1.71	5

Preparing Stock Solutions

The following data is based on the product molecular weight 342.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.92 mL	14.59 mL	29.18 mL
5 mM	0.58 mL	2.92 mL	5.84 mL
10 mM	0.29 mL	1.46 mL	2.92 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Damjanoska et al (2003) Neuroendocrine evidence that (S)-2-(chloro-5-fluoro-indol-l-yl)-1-methylethylamine fumarate (Ro 60-0175) is not a selective 5-hydroxytryptamine_2C receptor agonist. J.Pharmacol.Exp.Ther. 304 1209 PMID: 12604698

Kennett et al (2000) Effects of Ro 60 0175, a 5-HT_2C receptor agonist, in three animal models of anxiety. Eur.J.Pharmacol. 387 197 PMID: 10650160

Martin et al (1998) 5-HT_2C receptor agonists: pharmacological characteristics and therapeutic potential. J.Pharmacol.Exp.Ther. 286 913 PMID: 9694950

Jensen et al (2013) Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT_2A/5-HT_2C receptor agonists with pro-cognitive J.Med.Chem. 56 1211 PMID: 23301527

Keywords: Ro 60-0175 fumarate, supplier, Potent, selective, 5-HT2C, agonists, Serotonin, Receptors, Ro60-0175, 5-HT2C, Receptors, 5-HT2C, Receptors, Tocris Bioscience

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