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Tocris/Fostriecin sodium salt/1840/50U/50 ug

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货号: 1840/50U

品牌: Tocris

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Description: Potent PP2A and PP4 inhibitor

Chemical Name: (6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-one sodium salt

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent inhibitor of protein phosphatase types 2A (PP2A) and 4 (PP4) with IC₅₀ values of 1.5 nM and 3 nM respectively. Also exhibits weaker inhibition of topoisomerase II (IC₅₀ = 40 μM) and protein phosphatase type 1 (PP1) (IC₅₀ = 131 μM) with no apparent inhibition of protein phosphatase type 2B (PP2B). Active in vivo. Originally identified as an antitumor antibiotic from Streptomyces pulveraceous.

Technical Data

M. Wt	452.37
Formula	C₁₉H₂₆O₉PNa
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	87860-39-7
PubChem ID	16759606
InChI Key	XBUIKNRVGYFSHL-IAVQPKKASA-M
Smiles	[Na+].C[C@@](O)(C=C[C@H]1CC=CC(=O)O1)[C@@H](C[C@@H](O)C=C/C=CC=CCO)OP(O)([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	45.24	100

Preparing Stock Solutions

The following data is based on the product molecular weight 452.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.21 mL	11.05 mL	22.11 mL
5 mM	0.44 mL	2.21 mL	4.42 mL
10 mM	0.22 mL	1.11 mL	2.21 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Tunac et al (1983) Novel antitumor agents CI-920, PD 113,270 and PD 113,271. I. Taxonomy, fermentation and biological properties. J.Antibiot. 36 1595 PMID: 6689323

Walsh et al (1997) Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A. FEBS Lett. 416 230 PMID: 9373158

Hastie and Cohen (1998) Purification of protein phosphatase 4 catalytic subunit: inhibition by the antitumour drug fostriecin and other tumour suppressors and promoters. FEBS Lett. 431 357 PMID: 9714542

Keywords: Fostriecin sodium salt, supplier, Potent, PP2A, PP4, inhibitors, inhibits, Calcineurin, Protein, Ser/Thr, protein, phosphatases, 2A, 4, antibiotics, Protein, Ser/Thr, Phosphatases, Antibiotics, Protein, Ser/Thr, Phosphatases, Tocris Bioscience

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