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Tocris/Indirubin-3'-oxime/1813/50/50 mg

价格: ¥8460.00 市场价: 14100.00

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货号: 1813/50

品牌: Tocris

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Description: GSK-3β inhibitor. Also inhibits other protein kinases

Alternative Names: Indirubin-3'-monoxime

Chemical Name: 3-[1,3-Dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Protein kinase inhibitor; inhibits cyclin-dependent kinases (IC₅₀ = 0.18 - 3.33 μM) and GSK-3β (IC₅₀ = 0.19 μM). Inhibits CDK5- and GSK-3β-mediated tau phosphorylation, a process over-active in Alzheimer disease states. Also inhibits AMPK, LCK and SGK. Induces cell cycle arrest and inhibits cell proliferation.

Technical Data

M. Wt	277.28
Formula	C₁₆H₁₁N₃O₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	160807-49-8
PubChem ID	5326739
InChI Key	LDEWQRSYYHTQRA-UHFFFAOYSA-N
Smiles	ON=C1C2=CC=CC=C2NC/1=C1C(=O)NC2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	27.73	100
	ethanol	27.73	100

Preparing Stock Solutions

The following data is based on the product molecular weight 277.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.61 mL	18.03 mL	36.06 mL
5 mM	0.72 mL	3.61 mL	7.21 mL
10 mM	0.36 mL	1.8 mL	3.61 mL
50 mM	0.07 mL	0.36 mL	0.72 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Bain et al (2003) The specificities of protein kinase inhibitors: an update. Biochem.J. 371 199 PMID: 12534346

Hoessel et al (1999) Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nat.Cell.Biol. 1 60 PMID: 10559866

Leclerc et al (2001) Indirubins inhibit glycogen synthase kinase-3β and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. J.Biol.Chem. 276 251 PMID: 11013232

Keywords: Indirubin-3'-oxime, supplier, Protein, kinase, GSK-3β, GSK-3beta, inhibits, inhibitors, kinases, Cyclin-dependent, Induces, cell, cycle, arrest, antiproliferative, Broad, Spectrum, GSK, Glycogen, Synthase, 3, Cdk, Cyclin-Dependent, Carbohydrate, Metabolism, Cell, Cycle, Indirubin-3-oxime, Indirubin-3-mono, Indirubin-3'-monoxime, Glycogen, Synthase, Kinase, 3, Cyclin-dependent, Kinase, Broad, Spectrum, Protein, Kinase, Inhibitors, Cell, Cycle, Inhibitors, Glycogen, Synthase, Kinase, Glycogen, Synthase, Kinase, 3, Tocris Bioscience

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