Chemical Name: 2-[(Diphenylmethyl)sulfinyl]acetamide
Purity: ≥98% (HPLC)
Biological Activity
Technical Data
Solubility
Calculators
Datasheets
References
Biological Activity
Psychostimulant that displays neuroprotective and antiparkinsonian activity in a primate model of Parkinson's disease. Promotes vigilence and wakefulness without the central and peripheral side effects associated with conventional dopaminergic psychostimulants. Mechanism of action is not fully understood, possibly via modulation of catecholamine/GABAergic neurotransmission.
Technical Data
M. Wt
273.35
Formula
C15H15NO2S
Storage
Store at +4°C
Purity
≥98% (HPLC)
CAS Number
68693-11-8
PubChem ID
4236
InChI Key
YFGHCGITMMYXAQ-UHFFFAOYSA-N
Smiles
O=S(CC(N)=O)C(C2=CC=CC=C2)C1=CC=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
Solvent
Max Conc. mg/mL
Max Conc. mM
Solubility
DMSO
20.5
75
ethanol
2.73
10
Preparing Stock Solutions
The following data is based on the product molecular weight 273.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass
1 mg
5 mg
10 mg
1 mM
3.66 mL
18.29 mL
36.58 mL
5 mM
0.73 mL
3.66 mL
7.32 mL
10 mM
0.37 mL
1.83 mL
3.66 mL
50 mM
0.07 mL
0.37 mL
0.73 mL
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Product Datasheets
Certificate of Analysis / Product Datasheet
Safety Datasheet
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References
References are publications that support the products' biological activity.
Ferraroet al (1997) Modafinil: an antinarcoleptic drug with a different neurochemical profile to d-amphetamine and dopamine uptake blockers. Biol.Psychiatry 42 1181 PMID: 9426889
Jenneret al (2000) Antiparkinsonian and neuroprotective effects of modafinil in the mtpt-treated common marmoset. Exp.Brain Res. 133 178 PMID: 10968218
Madraset al (2006) Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro. J.Pharmacol.Exp.Ther. 319 561 PMID: 16885432
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