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Tocris/2-Methoxyestradiol/1807/10/10 mg

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货号: 1807/10

品牌: Tocris

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Description: Apoptotic and antiangiogenic agent

Chemical Name: (17β)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Apoptotic, antiproliferative and antiangiogenic agent, in vitro and in vivo; acts via an estrogen receptor-independent mechanism. Induces p53-induced apoptosis via two pathways: activation of p38 and NF-κB; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation. Also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly.

Compound Libraries

2-Methoxyestradiol is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	302.41
Formula	C₁₉H₂₆O₃
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	362-07-2
PubChem ID	66414
InChI Key	CQOQDQWUFQDJMK-SSTWWWIQSA-N
Smiles	OC1=C(OC)C=C2C(CC[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@H]4O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	15.12	50

Preparing Stock Solutions

The following data is based on the product molecular weight 302.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.31 mL	16.53 mL	33.07 mL
5 mM	0.66 mL	3.31 mL	6.61 mL
10 mM	0.33 mL	1.65 mL	3.31 mL
50 mM	0.07 mL	0.33 mL	0.66 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

D'Amato et al (1994) 2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site. Proc.Natl.Acad.Sci.U.S.A. 91 3964 PMID: 8171020

LaVallee et al (2002) 2-Methoxyestradiol inhibits proliferation and induces apoptosis independently of estrogen receptors α and β. Cancer Res. 62 3691 PMID: 12097276

LaVallee et al (2003) 2-Methoxyestradiol up-regulates death receptor 5 and induces apoptosis through activation of the extrinsic pathway. Cancer Res. 63 468 PMID: 12543804

Shimada et al (2003) Roles of p38 and c-jun NH₂-terminal kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis. Carcinogenesis 24 1067 PMID: 12807754

Keywords: 2-Methoxyestradiol, supplier, Apoptotic, agent, Apoptosis, Inducer, Antiangiogenics, Apoptosis, Inducers, Antiangiogenics, Apoptosis, Inducers, Tocris Bioscience

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