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Tocris/Gabexate mesylate/1798/50/50 mg

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货号: 1798/50

品牌: Tocris

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Description: Serine protease inhibitor; inhibits thrombin, trypsin, kallikrein and plasmin

Alternative Names: FOY

Chemical Name: 4-[[6-[(Aminoiminomethyl)amino]-1-oxohexyl]oxy]-benzoic acid ethyl ester mesylate

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Serine protease inhibitor; inhibits trypsin, plasmin, plasma kallikrein and thrombin (IC₅₀ values are 9.4, 30, 41 and 110 μM respectively). Antithrombotic in vitro and in vivo. Also inhibits LPS-induced TNF-α production, probably by inhibiting NF-κB and AP-1 activation.

Technical Data

M. Wt	417.48
Formula	C₁₆H₂₃N₃O₄.CH₃SO₃H
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	56974-61-9
PubChem ID	6604915
InChI Key	ICDMLAQPOAVWNH-HAAQQRBASA-N
Smiles	CS(O)(=O)=O.CCOC(=O)C1=CC=C(OC(=O)CCCCCNC(N)=N)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	phosphate buffered saline	20.87	50
	water	41.75	100

Preparing Stock Solutions

The following data is based on the product molecular weight 417.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.4 mL	11.98 mL	23.95 mL
5 mM	0.48 mL	2.4 mL	4.79 mL
10 mM	0.24 mL	1.2 mL	2.4 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Ohno et al (1980) FOY: [Ethyl p-(6-guanidinohexanoyloxy) benzoate] methanesulfonate as a serine proteinase inhibitor. I. Inhibition of thrombin and factor Xa in vitro. Thromb.Res. 19 579 PMID: 6449757

Ohno et al (1981) FOY: [Ethyl p-(6-guanidinohexanoyloxy) benzoate] methanesulfonate as a serine proteinase inhibitor. II. In vivo effect on coagulo-fibrinolytic system in comparison with heparin or aprotinin. Thromb.Res. 24 445 PMID: 6178174

Tamura et al (1977) Synthetic inhibitors of trypsin, plasmin, kallikrein, thrombin, C_1r and C₁ esterase. Biochim.Biophys.Acta 484 417 PMID: 143965

Yuksel et al (2003) Gabexate mesilate, a synthetic protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-α production by inhibiting activation of both nuclear factor-κB and activator protein-1 in human monocytes. J.Pharmacol.Exp.Ther. 305 298 PMID: 12649382

Keywords: Gabexate mesylate, supplier, Serine, protease, inhibits, inhibitors, thrombin, trypsin, kallikrein, plasmin, TNF-α, TNF-alpha, production, antithrombotic, agent, Proteases, Proteinases, Interleukins, Tumor, Necrosis, Factor-α, Factor-alpha, Cytokines, PAR, Receptors, Protease-Activated, proteinase, FOY, Protease-Activated, Receptors, Cytokines, Other, Proteases, Protease-Activated, Receptors, Tocris Bioscience

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