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Tocris/PKC β pseudosubstrate/1792/1/1 mg

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货号: 1792/1

品牌: Tocris

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Description: Selective cell-permeable PKC inhibitor peptide (attached to vector)

Alternative Names: Protein kinase C beta pseudosubstrate

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Selective cell-permeable peptide inhibitor of protein kinase C (IC₅₀ ~ 0.5 μM). Consists of amino acids 19 - 31 of PKC pseudosubstrate domain linked by a disulphide bridge to a cell permeabilisation Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the inhibitor peptide. Once inside the cell, the disulphide bonds are subjected to reduction in the cytoplasm leading to release of the inhibitor peptide.

Technical Data

M. Wt	3994.84
Formula	C₁₇₇H₂₉₄N₆₂O₃₈S₃
Sequence	CRQIKIWFQNRRMKWKK CRFARKGALRQKNV* (Modifications: Disulfide bridge between 17 -1*)
Storage	Store at -20°C
CAS Number	172308-76-8
PubChem ID	90488712
InChI Key	KIWJPYSSLFMLBZ-OSCDWKIESA-N
Smiles	[H]N[C@@H](CSSC[C@H](N[H])C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility	Soluble to 1 mg/ml in water

Solubility

Soluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 3994.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	0.25 mL	1.25 mL	2.5 mL
5 mM	0.05 mL	0.25 mL	0.5 mL
10 mM	0.03 mL	0.13 mL	0.25 mL
50 mM	0.01 mL	0.03 mL	0.05 mL

Product Datasheets

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service

Safety Datasheet

References

References are publications that support the products' biological activity.

Derossi et al (1994) The third helix of the antennapedia homeodomain translocates through biological membranes. J.Biol.Chem. 269 10444 PMID: 8144628

House and Kemp (1987) Protein kinase C contains a pseudosubstrate prototope in its regulatory domain. Science 238 1726 PMID: 3686012

Theodore et al (1995) Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse. J.Neurosci. 15 7158 PMID: 7472470

Keywords: PKC b pseudosubstrate, supplier, Selective, cell-permeable, PKC, inhibitors, inhibits, Protein, Kinases, C, beta, pseudosubstrate, PKCb, Protein, kinase, C, beta, pseudosubstrate, Protein, Kinase, C, Protein, Kinase, C, Tocris Bioscience

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