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Tocris/S 14506 hydrochloride/1771/10/10 mg

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货号: 1771

品牌: Tocris

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Description: Highly potent 5-HT_1A agonist; displays unique binding mechanism

Chemical Name: 4-Fluoro-N-[2-[4-(7-methoxy-1-naphthalenyl)-1-piperazinyl]ethyl]benzamide hydrochloride

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Highly potent selective 5-HT_1A receptor full agonist (pK_i values are 9.0, 6.6, 7.5, 6.6 and < 6.0 for 5-HT_1A, 5-HT_1B, 5-HT_1C, 5-HT₂ and 5-HT₃ receptors respectively). Possibly binds between the agonist binding site and the G protein interaction switch site, affecting the activation mechanism, and may display positive cooperativity. Anxiolytic following central administration in vivo.

Compound Libraries

S 14506 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	443.94
Formula	C₂₄H₂₆FN₃O₂.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	286369-38-8
PubChem ID	131905
InChI Key	HWLZKPKZVOLFGK-UHFFFAOYSA-N
Smiles	Cl.COC1=CC2=C(C=CC=C2C=C1)N1CCN(CCNC(=O)C2=CC=C(F)C=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	40.75	100
	ethanol	4.07	10

Preparing Stock Solutions

The following data is based on the product molecular weight 443.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.25 mL	11.26 mL	22.53 mL
5 mM	0.45 mL	2.25 mL	4.51 mL
10 mM	0.23 mL	1.13 mL	2.25 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Lima et al (1997) Atypical in vitro and in vivo binding of [³H]S-14506 to brain 5-HT_1A receptors. J.Neural Transm. 104 1059 PMID: 9503258

Milligan et al (2001) S 14506: novel receptor coupling at 5-HT_1A receptors. Neuropharmacology 40 334 PMID: 11166326

Colpaert et al (1992) S 14506: a novel, potent, high-efficacy 5-HT_1A agonist and potential anxiolytic agent. Drug Dev.Res. 26 21 PMID:

Keywords: S 14506 hydrochloride, supplier, potent, 5-HT1A, agonists, Serotonin, Receptors, S14506, hydrochloride, 5-HT1A, Receptors, Tocris Bioscience

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