UniProtSummary | FUNCTION:SwissProt:Q9UQL6#ResponsIBLeforthedeacetylationoflysineresiduesontheN-terminalpartofthecorehistones(H2A,H2B,H3andH4).Histonedeacetylationgivesatagforepigeneticrepressionandplaysanimportantroleintranscriptionalregulation,cellcycleprogressionanddevelopmentalevents.Histonedeacetylasesactviatheformationoflargemultiproteincomplexes.InvolvedinmusclematurationbyrepressingtranscriptionofmyocyteenhancerMEF2C.Duringmuscledifferentiation,itshuttlesintothecytoplasm,allowingtheexpressionofmyocyteenhancerfactors. SIZE:1122aminoacids;121992Da SUBUNIT:InteractswithBCOR,HDAC7,HDAC9,CTBP1,MEF2C,NCOR2,NRIP1,PHB2anda14-3-3chaperoneprotein.InteractswithJARID1B. SUBCELLULARLOCATION:Nucleus.Cytoplasm.Note=Shuttlesbetweenthenucleusandthecytoplasm.Inmusclecells,itshuttlesintothecytoplasmduringmyocytedifferentiation.Theexporttocytoplasmdependsontheinteractionwitha14-3-3chaperoneproteinandisduetoitsphosphorylationatSer-259andSer-498byCaMK.TISSUESPECIFICITY:Ubiquitous.DOMAIN:SwissProt:Q9UQL6Thenuclearexportsequencemediatestheshuttlingbetweenthenucleusandthecytoplasm(Bysimilarity). PTM:PhosphorylatedbyCaMKatSer-259andSer-498.Thephosphorylationisrequiredfortheexporttothecytoplasm.&Ubiquitinated.Polyubiquitinationhoweverdoesnotleadtoitsdegradation. SIMILARITY:Belongstothehistonedeacetylasefamily.Type2subfamily. |