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Tocris/Cisapride/1695/50/50 mg

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货号: 1695/50

品牌: Tocris

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Description: 5-HT₄ agonist; stimulates intestinal ACh release

Alternative Names: R 51619

Chemical Name: (±)-4-Amino-5-chloro-N-[1-[(3R*,4S*)-3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

5-HT₄ receptor agonist and gastrokinetic agent. Stimulates intestinal acetylcholine release, possibly via 5-HT₄ receptor-dependent and -independent mechanisms, leading to increased intestinal motility.

Compound Libraries

Cisapride is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	465.95
Formula	C₂₃H₂₉ClFN₃O₄
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	81098-60-4
PubChem ID	6917698
InChI Key	DCSUBABJRXZOMT-IRLDBZIGSA-N
Smiles	CO[C@H]1CN(CCCOC2=CC=C(F)C=C2)CC[C@H]1NC(=O)C1=C(OC)C=C(N)C(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	46.59	100

Preparing Stock Solutions

The following data is based on the product molecular weight 465.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.15 mL	10.73 mL	21.46 mL
5 mM	0.43 mL	2.15 mL	4.29 mL
10 mM	0.21 mL	1.07 mL	2.15 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Briejer et al (1993) Cisapride and a structural analogue, R 76,186, are 5-hydroxytryptamine₄ (5-HT₄) receptor agonists on the guinea-pig colon ascendens. Naunyn Schmiedebergs Arch.Pharmacol. 347 464 PMID: 8321323

Schuurkes et al (1985) Motor-stimulating properties of cisapride on isolated gastrointestinal preparations of the guinea pig. J.Pharmacol.Exp.Ther. 234 775 PMID: 3897516

Taniyama et al (1991) Cisapride stimulates motility of the intestine via the 5-hydroxytryptamine receptors. J.Pharmacol.Exp.Ther. 258 1098 PMID: 1890614

Keywords: Cisapride, supplier, 5-HT4, agonists, stimulates, Serotonin, Receptors, 5-Hydroxytryptamine, stimulate, ACh, acetylcholine, release, nicotinic, muscarinic, nAChR, R51619, R, 51619, Other, Acetylcholine, 5-HT4, Receptors, Non-selective, Muscarinics, 5-HT4, Receptors, Tocris Bioscience

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