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Tocris/T 0156 hydrochloride/1676/10/10 mg

价格: ¥2268.00 市场价: 3780.00

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货号: 1676/10

品牌: Tocris

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Description: Highly potent, selective PDE5 inhibitor

Chemical Name: 1,2-Dihydro-2-[(2-methyl-4-pyridinyl)methyl]-1-oxo-8-(2-pyrimidinylmethoxy)-4-(3,4,5-trimethoxyphenyl)-2,7-naphthyridine-3-carboxylic acid methyl ester hydrochloride

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent and selective inhibitor of phosphodiesterase type 5 (PDE5); more selective than sildenafil (IC₅₀ values are 0.23, 56 and > 63000 nM for T 0156 and 3.6, 29 and > 270 nM for sildenafil at PDE5, PDE6 and PDEs 1 - 4 respectively). Selective over 30 other enzymes and receptors (IC₅₀ > 10 mM) and potentiates electrical field stimulation-induced relaxation of isolated rabbit corpus cavernosum. Active in vivo.

Licensing Information

Sold with the permission of Tanabe Seiyaku Co. Ltd.

Compound Libraries

T 0156 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	620.06
Formula	C₃₁H₂₉N₅O₇.HCl
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	324572-93-2
PubChem ID	9852041
InChI Key	RBJCBXAXUHCWBR-UHFFFAOYSA-N
Smiles	Cl.COC(=O)C1=C(C2=CC(OC)=C(OC)C(OC)=C2)C2=CC=NC(OCC3=NC=CC=N3)=C2C(=O)N1CC1=CC=NC(C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	14.59	25mM with gentle warming
	ethanol	14.59	25mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 620.06. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.61 mL	8.06 mL	16.13 mL
5 mM	0.32 mL	1.61 mL	3.23 mL
10 mM	0.16 mL	0.81 mL	1.61 mL
50 mM	0.03 mL	0.16 mL	0.32 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Mochida et al (2002) Enzymological and pharmacological profile of T-0156, a potent and selective phosphodiesterase type 5 inhibitor. Eur.J.Pharmacol. 456 91 PMID: 12450574

Mochida et al (2004) T-0156, a novel phosphodiesterase type 5 inhibitor, and sildenafil have different pharmacological effects on penile tumescence and electroretinogram in dogs. Eur.J.Pharmacol. 485 283 PMID: 14757152

Keywords: T 0156 hydrochloride, supplier, potent, selective, PDE5, inhibitors, inhibits, Phosphodiesterases, T0156, hydrochloride, Phosphodiesterases, Phosphodiesterases, Tocris Bioscience

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