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Tocris/SB 206553 hydrochloride/1661/50/50 mg

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货号: 1661/50

品牌: Tocris

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Description: Potent, selective 5-HT_2C/5-HT_2B antagonist. Orally active

Chemical Name: 3,5-Dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b']dipyrrole-1(2H)-carboxamide hydrochloride

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent and selective 5-HT_2B/5-HT_2C receptor antagonist (rat 5-HT_2B pA₂ = 8.89, human 5-HT_2C pK_i = 7.92). Displays > 80-fold selectivity over all other 5-HT receptor subtypes and a variety of other receptors (pK_i < 6). Centrally active following oral administration in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Compound Libraries

SB 206553 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	328.8
Formula	C₁₇H₁₆N₄O.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	1197334-04-5
PubChem ID	11957707
InChI Key	VGEMBOFBPSNOIO-UHFFFAOYSA-N
Smiles	Cl.CN1C=CC2=CC3=C(CCN3C(=O)NC3=CC=CN=C3)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	32.88	100

Preparing Stock Solutions

The following data is based on the product molecular weight 328.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.04 mL	15.21 mL	30.41 mL
5 mM	0.61 mL	3.04 mL	6.08 mL
10 mM	0.3 mL	1.52 mL	3.04 mL
50 mM	0.06 mL	0.3 mL	0.61 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Forbes et al (1995) 5-Methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrrolo[2,3-f]indole: a novel 5-HT_2C/5-HT_2B receptor antagonist with improved affinity, selectivity and oral activity. J.Med.Chem. 38 2524 PMID: 7629791

Kennett et al (1996) In vitro and in vivo profile of SB 206553, a potent 5-HT_2C/5-HT_2B receptor antagonist with anxiolytic-like properties. Br.J.Pharmacol. 117 427 PMID: 8821530

Porras et al (2002) 5-HT_2A and 5-HT_2C/2B receptor subtypes modulate dopamine release induced in vivo by amphetamine and morphine in both the rat nucleus accumbens and striatum. Neuropsychopharmacology 26 311 PMID: 11850146

Keywords: SB 206553 hydrochloride, supplier, Potent, selective, 5-HT2C/5-HT2B, antagonists, Serotonin, 5-HT2B, Receptors, 5-HT2C, SB206553, hydrochloride, GlaxoSmithKline, GSK, 5-HT2C, Receptors, 5-HT2B, Receptors, 5-HT2C, Receptors, Tocris Bioscience

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