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Tocris/IEM 1460/1636/50/50 mg

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货号: 1636/50

品牌: Tocris

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Description: Open-channel blocker of AMPA currents; selective for non-GluR2-containing receptors

Chemical Name: N,N,H,-Trimethyl-5-[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]-1-pentanaminiumbromide hydrobromide

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Voltage-dependent open-channel blocker of AMPA receptors. Selective for GluR2 subunit-lacking (Ca²⁺-permeable) receptors over GluR2-containing receptors (IC₅₀ values are 2.6 and 1102 μM, respectively). Selectively blocks fast spiking interneuron but not medium spiny projection neuron in mouse striatum. Also blocks NMDA receptor-mediated currents. Anticonvulsant in vivo.

Compound Libraries

IEM 1460 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	454.33
Formula	C₁₉H₃₇N₂Br.HBr
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	121034-89-7
PubChem ID	6604954
InChI Key	CQTDZUSQSTUZDA-UHFFFAOYSA-M
Smiles	[Br-].Br.C[N+](C)(C)CCCCCNCC12CC3CC(C1)CC(C2)C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	phosphate buffered saline	45.43	100
	DMSO	45.43	100
	water	45.43	100

Preparing Stock Solutions

The following data is based on the product molecular weight 454.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.2 mL	11.01 mL	22.01 mL
5 mM	0.44 mL	2.2 mL	4.4 mL
10 mM	0.22 mL	1.1 mL	2.2 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Buldakova et al (1999) Characterization of AMPA receptor populations in rat brain cells by the use of subunit-specific open channel blocking drug, IEM-1460. Brain Res. 846 52 PMID: 10536213

Schlesinger et al (2005) Two mechanisms of action of the adamantane derivative IEM-1460 at human AMPA-type glutamate receptors. Br.J.Pharmacol. 145 656 PMID: 15834439

Gittis et al (2012) Selective inhibition of striatal fast-spiking interneurons causes dyskinesias. J.Neurosci. 31 15727 PMID: 22049415

Keywords: IEM 1460, supplier, Open-channel, blockers, AMPA, currents, selective, non-GluR2-containing, receptors, NMDA, blocks, Glutamate, Receptors, iGluR, Ionotropic, N-Methyl-D-Aspartate, IEM1460, neuron, neurones, medium, spiny, neurons, fast, spiking, interneurons, MSNs, FSIs, AMPA, Receptors, NMDA, Receptors, AMPA, Receptors, Tocris Bioscience

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