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Tocris/2-Methylthioadenosine diphosphate trisodium salt/1624/10/10 mg

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货号: 1624/10

品牌: Tocris

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Description: Potent agonist for P2Y₁, P2Y₁₂ and P2Y₁₃

Alternative Names: 2-(Methylthio)adenosine 5'-diphosphate, 2-Methylthio-ADP, MeSADP

Chemical Name: 2-(Methylthio)adenosine-5'-(trihydrogen diphosphate) trisodium salt

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent purinergic agonist displaying selectivity for P2Y₁, P2Y₁₂ and P2Y₁₃ receptors (pEC₅₀ = 8.29 and 9.05 for P2Y₁ and P2Y₁₂, EC₅₀ = 19 nM for P2Y₁₃). Induces aggregation of, and inhibits cAMP accumulation in, platelets in vitro.

Technical Data

M. Wt	539.24
Formula	C₁₁H₁₄N₅Na₃O₁₀P₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	475193-31-8
PubChem ID	442972
InChI Key	QASFUMOKHFSJGL-LAFRSMQTSA-N
Smiles	O[C@@H]1[C@@H](COP(OP([O-])([O-])=O)([O-])=O)O[C@@H](N3C2=NC(SC)=NC(N)=C2N=C3)[C@@H]1O.[Na+].[Na+].[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility	Soluble in water (supplied pre-dissolved at a concentration of 10mM)

Solubility

Soluble in water (supplied pre-dissolved at a concentration of 10mM)

Preparing Stock Solutions

The following data is based on the product molecular weight 539.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.85 mL	9.27 mL	18.54 mL
5 mM	0.37 mL	1.85 mL	3.71 mL
10 mM	0.19 mL	0.93 mL	1.85 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Macfarlane et al (1983) 2-Methylthioadenosine[β-³²P]diphosphate. An agonist and radioligand for the receptor that inhibits the accumulation of cyclic AMP in intact blood platelets. J.Clin.Invest. 71 420 PMID: 6298277

Sak and Webb (2002) A retrospective of recombinant P2Y receptor subtypes and their pharmacology. Arch.Biochem.Biophys. 397 131 PMID: 11747319

Zhang et al (2002) P2Y₁₃: identification and characterization of a novel Gαi-coupled ADP receptor from human and mouse. J.Pharmacol.Exp.Ther. 301 705 PMID: 11961076

Keywords: 2-Methylthioadenosine diphosphate trisodium salt, supplier, Potent, agonists, P2Y1, P2Y12, P2Y13, Receptors, Purinergic, purinoceptors, p2yt, 2-methylthio-ADP, 2MeSADP, ME2SADP, 2-(Methylthio)adenosine, 5'-diphosphate, 2-Methylthio-ADP, MeSADP, Purinergic, P2Y, Receptors, Purinergic, P2Y, Receptors, Tocris Bioscience

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