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Tocris/SB 366791/1615/50/50 mg

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货号: 1615/50

品牌: Tocris

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Description: Potent, selective, competitive TRPV1 antagonist

Chemical Name: 4'-Chloro-3-methoxycinnamanilide

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent, selective and competitive vanilloid TRPV1 receptor antagonist (pA₂ = 7.71 at hVR1); antagonizes hTRPV1 receptors activated by agonists, noxious heat, but not protons. Displays selectivity over a wide range of receptors and systems including CB₁ and CB₂ receptors, voltage-gated Ca²⁺ channels and the hyperpolarization-activated current (I_h). Also available as part of the Vanilloid TRPV1 Receptor Tocriset™.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Compound Libraries

SB 366791 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	287.75
Formula	C₁₆H₁₄ClNO₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	472981-92-3
PubChem ID	667594
InChI Key	RYAMDQKWNKKFHD-JXMROGBWSA-N
Smiles	COC1=CC=CC(NC(=O)C=CC2=CC=C(Cl)C=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	28.77	100
	ethanol	2.88	10

Preparing Stock Solutions

The following data is based on the product molecular weight 287.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.48 mL	17.38 mL	34.75 mL
5 mM	0.7 mL	3.48 mL	6.95 mL
10 mM	0.35 mL	1.74 mL	3.48 mL
50 mM	0.07 mL	0.35 mL	0.7 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Fowler et al (2003) Inhibition of C6 glioma cell proliferation by anandamide, 1-arachidonylglycerol, and by a water soluble phosphate ester of anandamide: variability in response and involvement of arachidonic acid. Biochem.Pharmacol. 66 757 PMID: 12948856

Gavva et al (2005) Proton activation does not alter antagonist interaction with the capsaicin-binding pocket of TRPV1. Mol.Pharmacol. 68 1524 PMID: 16135784

Gunthorpe et al (2004) Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist. Neuropharmacology 46 133 PMID: 14654105

Keywords: SB 366791, supplier, Potent, selective, competitive, TRPV1, VR1, antagonists, Vanillioids, Receptors, TRPV, Channels, Transient, Receptor, Potential, SB366791, GlaxoSmithKline, GSK, TRPV, TRPV, Tocris Bioscience

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