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Tocris/Ro 25-6981 maleate/1594/50/50 mg

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货号: 1594/50

品牌: Tocris

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Description: NR2B-selective NMDA antagonist

Chemical Name: (αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit. IC₅₀values are 0.009 and 52 μM for cloned receptor subunit combinations NR1C/NR2B and NR1C/NR2A respectively. Displays neuroprotectant effects in vivo and in vitro.

Compound Libraries

Ro 25-6981 maleate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	455.55
Formula	C₂₂H₂₉NO₂.C₄H₄O₄
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1312991-76-6
PubChem ID	53250677
InChI Key	FYJZEHCQSUBZDY-SEELMCCHSA-N
Smiles	OC(=O)C=C/C(O)=O.C[C@@H](CN1CCC(CC2=CC=CC=C2)CC1)[C@@H](O)C1=CC=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	45.55	100
	water	4.56	10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 455.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.2 mL	10.98 mL	21.95 mL
5 mM	0.44 mL	2.2 mL	4.39 mL
10 mM	0.22 mL	1.1 mL	2.2 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Fischer et al (1997) Ro 25-6981, a highly potent and selective blocker of N-Methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro. J.Pharmacol.Exp.Ther. 283 1285 PMID: 9400004

Kosowski and Liljequist (2004) The NR2B- selective N-methyl-D-aspartate receptor antagonist Ro 25-6981 [(±)-(R*,S*)-α-(4-hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidine propanol] potentiates the effect of nicotine on locomotor activity and dopamin J.Pharmacol.Exp.Ther. 311 560 PMID: 15256539

Lynch et al (2001) Pharmacological characterization of interactions of RO 25-6981 with the NR2B (ε2) subunit. Eur.J.Pharmacol. 416 185 PMID: 11290368

Keywords: Ro 25-6981 maleate, supplier, Subtype-selective, NR2B, antagonists, Glutamate, NMDA, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, Ro25-6981, maleate, NMDA, Receptors, NMDA, Receptors, Tocris Bioscience

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