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Tocris/SKF 83566 hydrobromide/1586/50/50 mg

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货号: 1586/50

品牌: Tocris

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Description: Potent, selective D₁-like antagonist

Chemical Name: 8-Bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrobromide

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent and selective D₁-like dopamine receptor antagonist (K_i~ 0.56 nM for D₁; K_B = 2 μM for D₂). Also antagonist at the vascular 5-HT₂ receptor (K_i = 11 nM). Displays selective inhibition of adenylyl cyclase 2 (AC2); inactive against AC1 or AC5. Centrally active following systemic administration in vivo.

Compound Libraries

SKF 83566 hydrobromide is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	413.15
Formula	C₁₇H₁₈BrNO.HBr
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	108179-91-5
PubChem ID	23581817
InChI Key	SDQJYYGODYRPBR-UHFFFAOYSA-N
Smiles	Br.CN1CCC2=CC(Br)=C(O)C=C2C(C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	41.31	100
	ethanol	10.33	25mM with gentle warming
	water	2.07	5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 413.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.42 mL	12.1 mL	24.2 mL
5 mM	0.48 mL	2.42 mL	4.84 mL
10 mM	0.24 mL	1.21 mL	2.42 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Fritts et al (1998) Locomotor stereotypy produced by dexbenzetimide and scopolamine is reduced by SKF 83566, not sulpiride. Pharmacol.Biochem.Behav. 60 639 PMID: 9678647

Meyer et al (1993) Effects of dopamine D₁ antagonists SCH23390 and SK&F83566 on locomotor activities in rats. Pharmacol.Biochem.Behav. 44 429 PMID: 8446676

Ohlstein and Berkowitz (1985) SCH 23390 and SK&F 83566 are antagonists at vascular dopamine and serotonin receptors. Eur.J.Pharmacol. 108 205 PMID: 3884345

Conley et al (2013) Development of a high-throughput screening paradigm for the discovery of small-molecule modulators of adenylyl cyclase: identification of an adenylyl cyclase 2 inhibitor. J.Pharmacol.Exp.Ther. 347 276 PMID: 24008337

Keywords: SKF 83566 hydrobromide, supplier, Potent, selective, D1-like, antagonists, Dopamine, Receptors, D5, dopaminergic, SKF83566, hydrobromide, D1, and, D5, Receptors, Adenylyl, Cyclase, D1, and, D5, Receptors, Tocris Bioscience

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