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Tocris/Purvalanol B/1581/50/50 mg

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货号: 1581/50

品牌: Tocris

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Description: Cyclin-dependent kinase inhibitor

Alternative Names: NG 95

Chemical Name: (2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Cyclin-dependent kinase inhibitor. IC₅₀ values are 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Selective over a range of other protein kinases (IC₅₀ > 10,000 nM). Shown to have antiproliferative properties, mediated by p42/p44 MAPK.

Licensing Information

Sold under license from the Regents of the University of California

Compound Libraries

Purvalanol B is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox I. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	432.91
Formula	C₂₀H₂₅ClN₆O₃
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	212844-54-7
PubChem ID	448991
InChI Key	ZKDXRFMOHZVXSG-HNNXBMFYSA-N
Smiles	CC(C)[C@H](CO)NC1=NC(NC2=CC(Cl)=C(C=C2)C(O)=O)=C2N=CN(C(C)C)C2=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. NaOH	43.29	100mM with gentle warming
	DMSO	43.29	100

Preparing Stock Solutions

The following data is based on the product molecular weight 432.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.31 mL	11.55 mL	23.1 mL
5 mM	0.46 mL	2.31 mL	4.62 mL
10 mM	0.23 mL	1.15 mL	2.31 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Gray et al (1998) Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science 281 533 PMID: 9677190

Gray et al (1999) ATP-site directed inhibitors of cyclin-dependent kinases. Curr.Med.Chem. 6 859 PMID: 10495356

Knockaert et al (2002) p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol. Oncogene 21 6413 PMID: 12226745

Keywords: Purvalanol B, supplier, Cyclin-dependent, protein, kinases, inhibitors, inhibits, Cdk, PurvalanolB, NG95, NG, 95, Cyclin-dependent, Kinase, Cyclin-dependent, Kinase, Tocris Bioscience

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