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Tocris/NADA/1568/5/5 mg

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货号: 1568

品牌: Tocris

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Description: Endogenous CB₁ agonist. Also vanilloid agonist and inhibitor of FAAH and AMT

Alternative Names: N-Arachidonyldopamine, AA-DA

Chemical Name: N-[2-(3,4-Dihydroxyphenyl)ethyl]-5Z,8Z,11Z,14Z-eicosatetraenamide

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent endogenous cannabinoid and vanilloid receptor agonist, with no action at dopamine receptors. Selective for CB₁ over CB₂ receptors (K_i values are 0.25 and 12 μM respectively), and potent agonist at TRPV1 (VR1) receptors (EC₅₀ ~ 50 nM). Metabolically stable and competitively inhibits FAAH and anandamide transport. Has cannabinoid and vanilloid actions in vivo.

Technical Data

M. Wt	439.64
Formula	C₂₈H₄₁NO₃
Storage	Desiccate at -20°C
CAS Number	199875-69-9
PubChem ID	5282105
InChI Key	MVVPIAAVGAWJNQ-DOFZRALJSA-N
Smiles	O=C(NCCC1=CC=C(O)C(O)=C1)CCCC=C/CC=C/C/C=CC/C=CCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility	Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml)

Solubility

Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml)

Preparing Stock Solutions

The following data is based on the product molecular weight 439.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.27 mL	11.37 mL	22.75 mL
5 mM	0.45 mL	2.27 mL	4.55 mL
10 mM	0.23 mL	1.14 mL	2.27 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Bisogno et al (2000) N-acyl-dopamines: novel synthetic CB₁ cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo. Biochem.J. 351 817 PMID: 11042139

De Petrocellis et al (2000) Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity. FEBS Lett. 483 52 PMID: 11033355

Huang et al (2002) An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors. Proc.Natl.Acad.Sci.U.S.A. 99 8400 PMID: 12060783

Keywords: NADA, supplier, Endogenous, CB1, agonists, vanilloid, inhibitors, inhibits, FAAH, AMT, TRPV1, cannabinoids, Receptors, Vanillioids, VR1, Channels, Transient, Receptor, Potential, cb1r, N-Arachidonyldopamine, AA-DA, CB1, Receptors, Tocris Bioscience

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