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Tocris/Piceatannol/1554/10/10 mg

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货号: 1554/10

品牌: Tocris

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Description: Inhibits TNF-induced NF-κB activation

Chemical Name: 4-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,2-benzenediol

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Anti-inflammatory, immunomodulatory and antiproliferative agent. Inhibits p56^lck and syk protein tyrosine kinases and inhibits TNF-induced NF-κB activation and gene expression. Synthesis results from conversion of resveratrol (Cat. No. 1418) by cytochrome P450 1B1.

Technical Data

M. Wt	244.25
Formula	C₁₄H₁₂O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	10083-24-6
PubChem ID	667639
InChI Key	CDRPUGZCRXZLFL-OWOJBTEDSA-N
Smiles	OC1=CC(C=CC2=CC(O)=C(O)C=C2)=CC(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	24.43	100
	ethanol	24.43	100

Preparing Stock Solutions

The following data is based on the product molecular weight 244.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.09 mL	20.47 mL	40.94 mL
5 mM	0.82 mL	4.09 mL	8.19 mL
10 mM	0.41 mL	2.05 mL	4.09 mL
50 mM	0.08 mL	0.41 mL	0.82 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Ashikawa et al (2002) Piceatannol inhibits TNF-induced NF-kB activation and NF-kB-mediated gene expression through suppression of IkBa kinase and p65 phosphorylation. J.Immunol. 169 6490 PMID: 12444159

Geahlen and McLaughlin (1989) Piceatannol (3,4,3',5'-tetrahydroxy-trans-stilbene) is a naturally occurring protein-tyrosine kinase inhibitor. Biochem.Biophys.Res.Commun. 165 241 PMID: 2590224

Oliver et al (1994) Inhibition of mast cell FceR1-mediated signalling and effector function by the syk-selective inhibitor, piceatannol. J.Biol.Chem. 269 29697 PMID: 7961959

Potter et al (2002) The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1. Br.J.Cancer 86 774 PMID: 11875742

Keywords: Piceatannol, supplier, Syk, p56lck, kinase, inhibitors, inhibits, TNF-induced, NF-κB, NF-kappaB, NF-kB, activation, Kinases, Nuclear, Factor, Kappa, B, Cytokine, Signaling, Signalling, Transcription, Factors, Src, Kinases, Syk, Kinase, NF-kB/IkB, NF-kB/IkB, Tocris Bioscience

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