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Tocris/CGP 7930/1513/50/50 mg

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货号: 1513/50

品牌: Tocris

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Description: Positive modulator at GABA_B receptors

Chemical Name: 3,5-bis(1,1-Dimethylethyl)-4-hydroxy-β,β-dimethyl-benzenepropanol

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Positive allosteric modulator of GABA_B receptors. Increases the potency and efficacy of GABA at both native and recombinant GABA_B receptors (EC₅₀ values are 5.37 and 4.60μM respectively) and enhances the inhibitory effect of the agonist L-baclofen in cultured cortical neurons. Reduces operant self-administration of ethanol in alcohol-preferring rats following i.p. administration.

Compound Libraries

CGP 7930 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	292.46
Formula	C₁₉H₃₂O₂
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	57717-80-3
PubChem ID	5024764
InChI Key	XLWJPQQFJNGUPA-UHFFFAOYSA-N
Smiles	CC(C)(CO)CC1=CC(=C(O)C(=C1)C(C)(C)C)C(C)(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	29.25	100
	ethanol	29.25	100

Preparing Stock Solutions

The following data is based on the product molecular weight 292.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.42 mL	17.1 mL	34.19 mL
5 mM	0.68 mL	3.42 mL	6.84 mL
10 mM	0.34 mL	1.71 mL	3.42 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Chen et al (2006) Differential modulation by the GABA_B receptor allosteric potentiator 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)-phenol (CGP7930) of synaptic transmission in the rat hippocampal CA1 area. J.Pharmacol.Exp.Ther. 317 1170 PMID: 16507713

Liang et al (2006) The GABA_B receptor allosteric modulator CGP7930, like baclofen, reduces operant self-administration of ethanol in alcohol-preferring rats. Neuropharmacology 50 632 PMID: 16406445

Urwyler et al (2001) Positive allosteric modulation of native and recombinant γ-aminobutyric acid_B receptors by 2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501. Mol.Pharmacol. 60 963 PMID: 11641424

Keywords: CGP 7930, supplier, Positive, modulators, GABAB, receptors, PAM, CGP7930, GABAB, Receptors, GABAB, Receptors, Tocris Bioscience

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