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Tocris/TMS/1509/50/50 mg

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货号: 1509/50

品牌: Tocris

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Description: Cytochrome P450 1B1 inhibitor

Alternative Names: (E)-2,3',4,5'-tetramethoxystilbene

Chemical Name: 1-[2,(3,5-Dimethoxyphenyl)ethenyl]-2,4-dimethoxybenzene

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent, selective and competitive inhibitor of cytochrome P450 1B1, an enzyme overexpressed in certain tumors (IC₅₀ = 6 nM). 50- and 520-fold selective over P450 1A1 and 1A2 respectively. Inhibits cancer cell growth in vitro.

Compound Libraries

TMS is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	300.35
Formula	C₁₈H₂₀O₄
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	24144-92-1
PubChem ID	5354004
InChI Key	JDBCWSHYEQUBLW-AATRIKPKSA-N
Smiles	COC1=CC(OC)=C(C=CC2=CC(OC)=CC(OC)=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	30.04	100
	ethanol	7.51	25

Preparing Stock Solutions

The following data is based on the product molecular weight 300.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.33 mL	16.65 mL	33.29 mL
5 mM	0.67 mL	3.33 mL	6.66 mL
10 mM	0.33 mL	1.66 mL	3.33 mL
50 mM	0.07 mL	0.33 mL	0.67 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Chun et al (2001) A new selective and potent inhibitor of human cytochrome P450 1B1 and its application to antimutagenesis. Cancer Res. 61 8164 PMID: 11719446

Kim et al (2002) Design, synthesis, and discovery of novel trans-stilbene analogues as potent and selective human cytochrome P450 1B1 inhibitors. J.Med.Chem. 45 160 PMID: 11754588

Nam et al (2001) Resveratrol analog, 3,5,2',4'-tetramethoxy-trans-stilbene, potentiates the inhibition of cell growth and induces apoptosis in human cancer cells. Arch.Pharm.Res. 24 441 PMID: 11693548

Keywords: TMS, supplier, Cytochrome, P450, 1B1, inhibitors, inhibits, CYP, (E)-2,3',4,5'-tetramethoxystilbene, Cytochrome, P450, Cytochrome, P450, Tocris Bioscience

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