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Tocris/Mycophenolic acid/1505/100/100 mg

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货号: 1505/100

品牌: Tocris

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Description: Inosine monophosphatase dehydrogenase inhibitor

Chemical Name: 6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Immunosuppressive agent with antiviral and antitumor effects in vitro and in vivo. Potently inhibits inosine monophosphate dehydrogenase, thus inhibiting de novo GTP synthesis leading to decreased RNA and DNA synthesis. Reversibly inhibits proliferation of T and B lymphocytes and antibody formation.

Compound Libraries

Mycophenolic acid is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	320.34
Formula	C₁₇H₂₀O₆
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	24280-93-1
PubChem ID	446541
InChI Key	HPNSFSBZBAHARI-RUDMXATFSA-N
Smiles	COC1=C(C)C2=C(C(=O)OC2)C(O)=C1CC=C(/C)CCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	32.03	100

Preparing Stock Solutions

The following data is based on the product molecular weight 320.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.12 mL	15.61 mL	31.22 mL
5 mM	0.62 mL	3.12 mL	6.24 mL
10 mM	0.31 mL	1.56 mL	3.12 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Allison et al (1993) Mechanisms of action of mycophenolic acid. Ann.N.Y.Acad.Sci. 696 63 PMID: 7906496

Chapman et al (1997) Distinct inhibitory effects of spinal endomorphin-1 and endomorphin-2 on evoked dorsal horn neuronal responses in the rat. Br.J.Pharmacol. 122 1537 PMID: 9422796

Eugui et al (1991) Lymphocyte-selective cytostatic and immunosuppressive effects of mycophenolic acid in vitro: role of deoxyguanosine nucleotide depeletion. Scand.J.Immunol. 33 161 PMID: 1826793

Goldberg et al (1998) Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain. J.Pharmacol.Exp.Ther. 286 1007 PMID: 9694962

Senda et al (1995) Mycophenolic acid, an inhibitor of IMP dehydrogenase that is also an immunosuppressive agent, suppresses the cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells. Transplantation 60 1143 PMID: 7482723

Zadina et al (1997) A potent and selective endogenous agonist for the μ-opiate receptor. Nature 386 499 PMID: 9087409

Keywords: Mycophenolic acid, supplier, Inosine, monophosphatase, dehydrogenases, inhibitors, inhibits, immunosuppressant, Other, Dehydrogenases, Immunosuppressants, Antivirals, Other, Dehydrogenases, Tocris Bioscience

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