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Millipore/15-101 | Akt phosphorylation Pathway Explorer MiniPack/15-101/3 vials/Pk
  • Millipore/15-101 | Akt phosphorylation Pathway Explorer MiniPack/15-101/3 vials/Pk

Millipore/15-101 | Akt phosphorylation Pathway Explorer MiniPack/15-101/3 vials/Pk

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货号: 15-101
品牌: Millipore
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    • Description
      CatalogueNumber15-101
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAktphosphorylationPathwayExplorerMiniPack
      AlternateNames
      • ProteinkinaseB
      • RAC-alphaserine/threonine-proteinkinase
      • racproteinkinasealpha
      • v-aktmurinethymomaviraloncogenehomolog1
      • murinethymomaviral(v-akt)oncogenehomolog-1
      BackgroundInformationPathwayExplorerAntibodyMiniPack:
      EachPathwayExplorerAntibodyMinipackcontainsthreerelatedantibodiesaspartofasignalingcascadeoracombinationoftotalandphosphorylatedformsofkeysignalingtargets.Eachofthethreeantibodiesare30%theoriginalpacksize.FullsizeversionsofeachofthePathwayExplorerantibodiesareavailableforsaleindividuallyunderthesamecatalognumberwiththeremovalof“SP”offofeachone(e.g.05-591SPcanbeorderedas05-591).

      Anti-Akt/PKB,PHDomain,
      cloneSKB1:
      Akt(proteinkinaseB),aserine/threoninekinase,hasemergedasacriticalenzymeinsignaltransductionpathwaysinvolvedincellproliferation,apoptosis,angiogenesis,anddiabetes.InmammalsthreeisoformsofAkt(α,β,γorAkt1,2,3)arereportedthatexhibitahighdegreeofhomology,butdifferslightlyinthelocalizationoftheirregulatoryphosphorylationsites.Aktαisthepredominantisoforminmosttissues,whereasthehighestexpressionofAktβisobservedintheinsulin-responsivetissues,andAktγisabundantinbraintissue.EachAktisoformiscomposedofthreefunctionallydistinctregions:anN-terminalpleckstrinhomology(PH)domainthatprovidesalipid-bindingmoduletodirectAkttoPIP3,acentralcatalyticdomain,andaC-terminalhydrophobicmotif.

      Anti-phospho-Akt(Thr308),
      clone50-1C-25orAnti-phospho-Akt1/PKBα(Ser473),clone11E6:
      Akt/PKBisaSer/ThrkinaseandamajorknowneffecterofthePI3Kinasepathway.ItisinvolvedinmultiplesignalingpathwaysthatrelatetomanyBIOLOGicalprocessesincludingmetabolism,apoptosis,cellcyclecontrol,angiogenesis,differentiation,andcellgrowthandproliferation.Inmammals,threeisoformsofAkt(Akt1/PKCα,Akt2/PKBβ,andAkt3/PKBγ)exists.Theyexhibitahighdegreeofhomology,butdifferslightlyinthelocalizationoftheirregulatoryphosphorylationsites.Akt1isthepredominantisoformthatisinmosttissuesandisthoughttohaveadominantroleingrowth,survival,embryonicdevelopment,andADIpocytedifferentiation.Akt2iscorrelatedwiththeregulationofglucosehomeostasisandisthepredominantisoformexpressedininsulin-responsivetissues.Akt3isabundantinbraintissue.EachAktisoformiscomposedofthreefunctionallydistinctregions:anN-terminalPleckstrinHomology(PH)domainthatprovidesalipid-bindingmodule,acentralcatalyticdomaincontainingThr308,andaC-terminalhydrophobicmotifcontainingSer473.TheactivationofAKTisdependentonadualregulatorymechanismthatrequiresbothitstranslocationtotheplasmamembraneanddualphosphorylationonThr308andSer473byPDK1andtheTORC2complex,respectively.

      *Seefullsizeversionsforcorrespondingreferences.
      ProductInformation
      Components
      • 05-591SPAnti-Akt/PKB,PHDomain,
        cloneSKB1
      • 05-802RSPAnti-phospho-Akt(Thr308),
        clone50-1C-25
      • 05-669SPAnti-phospho-Akt1/PKBα(Ser473),clone11E6
      Presentation3individualtubescontainingeitherAnti-Akt/PKB,PHDomain,cloneSKB1;Anti-phospho-Akt(Thr308),clone50-1C-25;orAnti-phospho-Akt1/PKBα(Ser473),clone11E6


      PropertiesEachvialis30%thesizeoftheparentcatalognumber
      StorageandShippingInformation
      Applications
      ApplicationThisAntibodypackcontainsAnti-Akt/PKBAntibody,PHDomain,Anti-phospho-AktAntibody(Thr308),Anti-phospho-Akt1/PKBαAntibody(Ser473).
      BiologicalInformation
      EntrezGeneNumber
      GeneSymbol
      • AKT
      • C-AKT
      • EC2.7.11.1
      • MGC99656
      • PKB
      • PKB-ALPHA
      • PRKBA
      • RAC
      • RAC-ALPHA
      • RAC-PK-alpha
      UniProtNumber
      UniProtSummaryFUNCTION:Generalproteinkinasecapableofphosphorylatingseveralknownproteins.PhosphorylatesTBC1D4.Signalsdownstreamofphosphatidylinositol3-kinase(PI(3)K)tomediatetheeffectsofvariousgrowthfactorssuchasplatelet-derivedgrowthfactor(PDGF),epidermalgrowthfactor(EGF),insulinandinsulin-likegrowthfactorI(IGF-I).Playsaroleinglucosetransportbymediatinginsulin-inducedtranslocationoftheGLUT4glucosetransportertothecellsurface.MediatestheantiapoptoticeffectsofIGF-I.Mediatesinsulin-stimulatedproteinsynthesis,partlybyplayingaroleinbothinsulin-inducedphosphorylationof4E-BP1andininsulin-inducedactivationofp70S6kinase.Promotesglycogensynthesisbymediatingtheinsulin-inducedactivationofglycogensynthase.
      CATALYTICACTIVITY:ATP+aprotein=ADP+aphosphoprotein.
      ENZYMEREGULATION:Threespecificsites,oneinthekinasedomain(Thr-308)andthetwootheronesintheC-terminalregulatoryregion(Ser-473andTyr-474),needtobephosphorylatedforitsfullactivation.
      SUBUNIT:InteractswithCENTG1isoform2(PIKE-A)inthepresenceofguaninenucleotides.TheC-terminusinteractswithCCDC88A/GRDNandTHEM4.InteractswithAKTIP.Interacts(viaPHdomain)withMTCP1,TCL1AANDTCL1B.InteractswithCDKN1B;theinteractionphosphorylatesCDKN1Bpromoting14-3-3bindingandcell-cycleprogression.
      SUBCELLULARLOCATION:Cytoplasm.Nucleus.Cellmembrane.Note=Nucleusafteractivationbyintegrin-linkedproteinkinase1(ILK1).NucleartranslocationisenhancedbyinteractionwithTCL1A.
      TISSUESPECIFICITY:Inallhumancelltypessofaranalyzed.
      DOMAIN:BindingofthePHdomaintothephosphatidylinositol3-kinasealpha(PI(3)K)resultsinitstargetingtotheplasmamembrane.
      DOMAIN:TheAGC-kinaseC-terminalmediatesinteractionwithTHEM4.
      PTM:PhosphorylationonThr-308,Ser-473andTyr-474isrequiredforfullactivity.Ser-473phosphorylationbytheRictor-mTorcomplexfavorsThr-308phosphorylationbyPDPK1.Ser-473phosphorylationisenhancedbyinteractionwithCENTG1isoform2(PIKE-A).Ser-473phosphorylationisenhancedinfocalcorticaldysplasiaswithTaylor-typeballooncells.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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