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Tocris/Formoterol hemifumarate/1448/10/10 mg

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货号: 1448/10

品牌: Tocris

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Description: Potent and selective β₂ agonist

Alternative Names: BD 40A

Chemical Name: (±)-(R,R)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl] formamide hemifumarate

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent, selective and long-acting β₂-adrenoceptor agonist. Displays 330-fold selectivity for β₂ over β₁ receptors (pK_d values are 8.12 and 5.58 respectively). Potently relaxes guinea pig trachea (pD₂ = 9.29), and is longer-acting and 100-fold more potent than salbutamol.

Compound Libraries

Formoterol hemifumarate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	402.45
Formula	C₁₉H₂₄N₂O₄.½C₄H₄O₄
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	43229-80-7
PubChem ID	9832292
InChI Key	OBRNDARFFFHCGE-PERKLWIXSA-N
Smiles	[H]OC(=O)C=CC(=O)O[H].COC1=CC=C(C=C1)C[C@H](C)NC[C@@H](O)C1=CC(NC([H])=O)=C(O)C=C1.COC1=CC=C(C=C1)C[C@H](C)NC[C@@H](O)C1=CC(NC([H])=O)=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility	Soluble to 50 mM in DMSO

Solubility

Soluble to 50 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 402.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.48 mL	12.42 mL	24.85 mL
5 mM	0.5 mL	2.48 mL	4.97 mL
10 mM	0.25 mL	1.24 mL	2.48 mL
50 mM	0.05 mL	0.25 mL	0.5 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Anderson (1993) Formoterol: pharmacology, molecular basis of agonism, and mechanism of long duration of a highly potent and selective β₂-adrenoceptor agonist bronchodilator. Life Sci. 52 2145 PMID: 8099696

Decker et al (1982) Effects of N-aralkyl substitution of β-agonists on α- and β-adrenoceptor subtypes: pharmacological studies and binding assays. J.Pharm.Pharmacol. 34 107 PMID: 6121868

Naline et al (1994) Relaxant effects and durations of action of formoterol and salmeterol on the isolated human bronchus. Eur.Respir.J. 7 914 PMID: 7914176

Keywords: Formoterol hemifumarate, supplier, Potent, selective, β2-adrenoceptor, α2-adrenoceptor, beta2-adrenoceptor, b2-adrenoceptor, β2-adrenergic, α2-adrenergic, beta2-adrenergic, b2-adrenergic, agonists, Receptors, BD40A, BD, 40A, Adrenergic, Beta-2, Receptors, Adrenergic, Beta-2, Receptors, Tocris Bioscience

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