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StimulatesCl-secretionviatheactivationofhKCa3.1(IK1)potassiumchannelsandanapicalCl-conductancecarriedbytheCFTRchannel.Morepotentthanitsanalog1-EBIO(Cat.No.1041).
DCEBIOisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Thefollowingdataisbasedontheproductmolecularweight231.08.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Referencesarepublicationsthatsupporttheproducts'biologicalactivity.
Singhetal(2001)Benzimidazoloneactivatorsofchloridesecretion:potentialtherapeuticsforcysticfibrosisandchronicobstructivepulmonarydisease.J.Pharmacol.Exp.Ther.296600PMID:11160649
HamiltonandKiesslingetal(2006)DCEBIOstimulatesCl-secretioninthemousejejunum.Am.J.Physiol.CellPhysiol.290152PMID:16135545
Keywords:DCEBIO,supplier,potent,Activators,hIK1/Cl-,conductance,K+,channels,Potassium,KCa,KCa3.1,Channels,ca2+-activated,ca2+-dependent,Chloride,Ca2+-Activated,Potassium,Channels,CFTR,CFTR,TocrisBioscience
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