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Tocris/Naloxone benzoylhydrazone/1419/10/10 mg

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货号: 1419

品牌: Tocris

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Description: Full κ agonist, partial μ and δ agonist and antagonizes agonist-induced activation of NOP

Alternative Names: NalBzOH

Chemical Name: [(5α)-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-ylidene] benzoic acid hydrazide

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Mixed opioid receptor agonist/antagonist. Acts as a potent and full agonist at κ, a partial agonist at μ and δ opioid receptors (pEC₅₀ values are 9.45, 8.74 and 8.61 in a cAMP assay, 9.70, 8.59 and 8.49 in a [³⁵S]GTPγS binding assay respectively). Fails to exert agonist effects at NOP receptors and antagonizes agonist-induced NOP activation. Stimulates κ-, μ- and δ-mediated analgesia and blocks NOP-induced supraspinal nociception.

Compound Libraries

Naloxone benzoylhydrazone is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	445.52
Formula	C₂₆H₂₇N₃O₄
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	119630-94-3
PubChem ID	9601084
InChI Key	AKXCFAYOTIEFOH-XTNAHFASSA-N
Smiles	O[C@@]23[C@@]([C@]5([H])/C(CC3)=N/NC(C6=CC=CC=C6)=O)(CC4)C1=C(O5)C(O)=CC=C1C[C@H]2N4CC=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	22.28	50

Preparing Stock Solutions

The following data is based on the product molecular weight 445.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.24 mL	11.22 mL	22.45 mL
5 mM	0.45 mL	2.24 mL	4.49 mL
10 mM	0.22 mL	1.12 mL	2.24 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Connor and Kitchen (2006) Has the sun set on κ₃-opioid receptors? Br.J.Pharmacol 147 349 PMID: 16402044

Gistrak et al (1989) Pharmacological actions of a novel mixed opiate agonist/antagonist: naloxone benzoylhydrazone J.Pharmacol.Exp.Ther. 251 469 PMID: 2553921

Olianas et al (2006) Agonist activity of naloxone benzoylhydrazone at recombinant and native opioid receptors. Br.J.Pharmacol. 147 360 PMID: 16402046

Keywords: Naloxone benzoylhydrazone, supplier, κ-opioid, kappa-opioid, agonists, partial, μ-opioid, mu-opioid, δ-opioid, delta-opioid, antagonists, NOP, Opioids, Receptors, NalBzOH, Miscellaneous/Non-selective, Opioids, Tocris Bioscience

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