BackgroundInformation | Histonedeacetylationactsatagforepigeneticrepressionandplaysanimportantroleintranscriptionalregulation,cellcycleprogressionanddevelopmentalevents.HDAC4isahistonedeacetylasewhichdeacetylateslysinesonthecorehistones.HDAC4accumulatesinthenucleiofmyotubes,suggestinginvolvementinmuscledifferentiation.HDAC4doesnotbindDNAdirectlybutinteractswiththemyocyteenhancerfactorsMef2a,Mef2c,andMef2d.HDAC4alsointeractswiththebreastcancer-associatedtranscriptionalrepressorPLU-1/JARID1B,theNr2c1/TR2nuclearreceptor,aswellasthe14-3-3chaperoneprotein,inaphosphorylationdependentmanner.ItalsoformspartofamultiproteincomplexwithRbAp48andHDAC3. |