Source | HumanRasBindingDomain(RBD,residues1-149)ofRaf-1,expressedinE.coli. |
SpecificActivity | ForSpecificActivitydata,refertotheCertificateofAnalysisforindividuallotsofthisenzyme. |
EntrezGeneNumber | |
EntrezGeneSummary | MembersoftheRASsuperfamilyofGTP-bindingproteins,whichincludesMRAS,aremembrane-anchored,intracellularsignaltransducersresponsIBLeforavarietyofnormalcellularfunctions.Theyareoncogenicallyactivatedinasignificantfractionoftumors.[suppliedbyOMIM] |
GeneSymbol | - MRAS
- RRAS3
- M-RAS
- FLJ42964
- R-RAS3
- M-RAs
|
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:O14807#Mayserveasanimportantsignaltransducerforanovelupstreamstimuliincontrollingcellproliferation.WeaklyactivatestheMAPkinasepathway. SIZE:208aminoacids;23846Da SUBUNIT:InteractswithRGL3(Bysimilarity). SUBCELLULARLOCATION:Cellmembrane;Lipid-anchor;Cytoplasmicside(Potential). TISSUESPECIFICITY:Expressionhighlyrestrictedtothebrainandheart. SIMILARITY:SwissProt:O14807##BelongstothesmallGTPasesuperfamily.Rasfamily. |