Description: Kir6 (KATP) channel opener; active enantiomer of cromakalim (Cat. No. 1377)
Alternative Names: BRL 38227
Chemical Name: (3S,4R)-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile
Purity: ≥99% (HPLC)
Biological Activity
Technical Data
Solubility
Calculators
Datasheets
References
Biological Activity
Active enantiomer of the prototypical Kir6 (KATP) channel opener cromakalim (Cat. No. 1377). Hypotensive and airways relaxant. IC50 = 490 nM in guinea pig trachea.
Licensing Information
Sold under license
Technical Data
M. Wt
286.33
Formula
C16H18N2O3
Storage
Store at RT
Purity
≥99% (HPLC)
CAS Number
94535-50-9
PubChem ID
93504
InChI Key
TVZCRIROJQEVOT-CABCVRRESA-N
Smiles
O=C1CCCN1[C@H]2[C@H](O)C(C)(C)OC3=C2C=C(C#N)C=C3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
Solvent
Max Conc. mg/mL
Max Conc. mM
Solubility
DMSO
2.86
10
Preparing Stock Solutions
The following data is based on the product molecular weight 286.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass
1 mg
5 mg
10 mg
1 mM
3.49 mL
17.46 mL
34.92 mL
5 mM
0.7 mL
3.49 mL
6.98 mL
10 mM
0.35 mL
1.75 mL
3.49 mL
50 mM
0.07 mL
0.35 mL
0.7 mL
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Product Datasheets
Certificate of Analysis / Product Datasheet
Safety Datasheet
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References
References are publications that support the products' biological activity.
Buckleet al (1991) Synthesis and smooth muscle relaxant activity of a new series of potassium channel activators: 3-amido-1,1-dimethylindan-2-ols. J.Med.Chem. 34 919 PMID: 2002472
Noacket al (1992) Potassium channel modulation in rat portal vein by ATP depletion: a comparison with the effects of levcromakalim (BRL 38227). Br.J.Pharmacol. 107 945 PMID: 1467843
Tayloret al (1992) The inhibitory effects of cromakalim and its active enantiomer BRL 38227 against various agonists in guinea pig and human airways. J.Pharmacol.Exp.Ther. 261 429 PMID: 1578358
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