BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Highlypotentandselectivecompetitiveantagonistforα3β2subunit-containingnicotinicreceptors(IC50=0.5-3.5nMatα3β2expressedinXenopusoocytes).Alsopotentlyblocksβ3-containingneuronalnicotinicreceptors.Displays>200-foldselectivityforα3β2overα2β2,α4β2andα3β4.
LicensingInformation
SoldunderlicensefromtheUniversityofUtah.
TechnicalData
| M.Wt | 1710.99 |
| Formula | C67H103N23O22S4 |
| Sequence | GCCSNPVCHLEHSNLC (Modifications:Disulfidebridgebetween2-8,3-16,Cys-16=C-terminalamide) |
| Storage | Desiccateat-20°C |
| CASNumber | 175735-93-0 |
| PubChemID | 57340508 |
| InChIKey | DUQYFGMBLOPGBY-XCQLYXDWSA-N |
| Smiles | [H]NCC(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CNC=N3)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC3=CNC=N3)NC2=O)C(N)=O)NC1=O)C(C)C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto1mg/mlinwater |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight1710.99.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|
| 1mM | 0.58mL | 2.92mL | 5.84mL |
| 5mM | 0.12mL | 0.58mL | 1.17mL |
| 10mM | 0.06mL | 0.29mL | 0.58mL |
| 50mM | 0.01mL | 0.06mL | 0.12mL |
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