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Tocris/cAMPS-Sp, triethylammonium salt/1333/1/1 mg

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货号: 1333/1

品牌: Tocris

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Description: Cell-permeable cAMP analog

Chemical Name: (S)-Adenosine, cyclic 3',5'-(hydrogenphosphorothioate) triethylammonium

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Cell-permeable cAMP analog that activates cAMP receptor proteins such as PKA and cAMP-regulated guanine nucleotide exchange factor. Enantiomer cAMPS-Rp, triethylammonium salt (Cat. No. 1337) also available.

Technical Data

M. Wt	446.46
Formula	C₁₀H₁₂N₅O₅PS.C₆H₁₅N
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	93602-66-5
PubChem ID	57369926
InChI Key	OXIPZMKSNMRTIV-UHFFFAOYSA-N
Smiles	[H][C@@]([C@@](O[C@@H](N3C=NC4=C3N=CN=C4N)[C@@H]2O)([H])CO1)2O[P@]1([S-])=O.CC[NH+](CC)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	44.65	100

Preparing Stock Solutions

The following data is based on the product molecular weight 446.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.24 mL	11.2 mL	22.4 mL
5 mM	0.45 mL	2.24 mL	4.48 mL
10 mM	0.22 mL	1.12 mL	2.24 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Dostmann et al (1990) Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates. J.Biol.Chem. 265 10484 PMID: 2162349

Kawasaki et al (1998) A family of cAMP-binding proteins that directly activate Rap1. Science 282 2275 PMID: 9856955

Lin et al (2006) Ethanol inhibition of NMDA-induced responses and actute tolerance to the inhibition in rat rostral ventrolateral medulla in vivo: Involvement of cAMP-dependent protein kinases. Neuropharmacology 51 747 PMID: 16806304

O'Brian et al (1982) A kinetic study of interactions of (R_p)- and (S_p)-adenosine cyclic 3',5'-phosphorothioates with type II bovine cardiac muscle adenosine cyclic 3',5'-phosphate dependent protein kinase. Biochemistry 21 4371 PMID: 6289880

Keywords: cAMPS-Sp, triethylammonium salt, supplier, Cell-permeable, cAMP, Cyclic, adenosines, Monophosphate, cAMP, Protein, Kinase, A, cAMP, Tocris Bioscience

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