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Tocris/Chelerythrine chloride/1330/5/5 mg

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货号: 1330/5

品牌: Tocris

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Description: Cell-permeable protein kinase C inhibitor

Chemical Name: 1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium chloride

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Cell-permeable inhibitor of protein kinase C (IC₅₀ = 660 nM); competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Has a wide range of biological activities, including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. Activates MAPK pathways, independent of PKC inhibition. Inhibits binding of Bcl_XL to Bak (IC₅₀ = 1.5 μM) or Bad proteins and stimulates apoptosis.

Technical Data

M. Wt	383.83
Formula	C₂₁H₁₈ClNO₄
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	3895-92-9
PubChem ID	72311
InChI Key	WEEFNMFMNMASJY-UHFFFAOYSA-M
Smiles	C[N+](C3=C2C=CC4=C3C=C(OCO5)C5=C4)=CC1=C2C=CC(OC)=C1OC.[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	3.84	10
	water	3.84	10

Preparing Stock Solutions

The following data is based on the product molecular weight 383.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.61 mL	13.03 mL	26.05 mL
5 mM	0.52 mL	2.61 mL	5.21 mL
10 mM	0.26 mL	1.3 mL	2.61 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Chan et al (2003) Identification of chelerythrine as an inhibitor of BclXL function. J.Biol.Chem. 278 20453 PMID: 12702731

Herbert et al (1990) Chelerythrine is a potent and specfic inhibitor of protein kinase C. Biochem.Biophys.Res.Commun. 172 993 PMID: 2244923

Lee et al (1998) Angoline and chelerythrine, benzophenanthridine alkaloids that do not inhibit protein kinase C. J.Biol.Chem. 273 19829 PMID: 9677417

Yu et al (2000) Activation of p38 and c-Jun N-terminal kinase pathways and induction of apoptosis by chelerythrine do not require inhibition of protein kinase C. J.Biol.Chem. 275 9612 PMID: 10734112

Keywords: Chelerythrine chloride, supplier, Potent, protein, kinase, C, inhibitors, inhibits, PKC, Kinases, Protein, Kinase, C, Protein, Kinase, C, Tocris Bioscience

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