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Tocris/ZM 336372/1321/50/50 mg

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货号: 1321/50

品牌: Tocris

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Description: Potent, selective c-Raf inhibitor

Chemical Name: 3-(Dimethylamino)-N-[3-[(4-hydroxybenzoyl)-amino]-4-methylphenyl]benzamide

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent, selective inhibitor of c-Raf in vitro (IC₅₀ = 70 nM for inhibition of human c-Raf). Shows 10-fold selectivity over B-Raf. Also inhibits SAPK2/p38 (IC₅₀ = 2 μM). Selective over 17 other protein kinases including PKA, PKC, p42 MAPK, CDK1 and SAPK1/JNK (up to 50 μM). Also available as part of the MAPK Cascade Inhibitor Tocriset™.

Licensing Information

Sold with the permission of AstraZeneca Ltd

Compound Libraries

ZM 336372 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox I. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	389.45
Formula	C₂₃H₂₃N₃O₃
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	208260-29-1
PubChem ID	5311006
InChI Key	SCJNCDSAIRBRIA-DOFZRALJSA-N
Smiles	CN(C)C1=CC(=CC=C1)C(=O)NC1=CC=C(C)C(NC(=O)C2=CC=C(O)C=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility	Soluble to 100 mM in DMSO

Solubility

Soluble to 100 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 389.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.57 mL	12.84 mL	25.68 mL
5 mM	0.51 mL	2.57 mL	5.14 mL
10 mM	0.26 mL	1.28 mL	2.57 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Hall-Jackson et al (1999) Paradoxical activation of Raf by a novel Raf inhibitor. Chem.Biol. 6 559 PMID: 10421767

Wartenberg et al (2001) Down-regulation of intrinsic p-glycoprotein expression in multicellular prostate tumor spheroids by reactive oxygen species. J.Biol.Chem. 276 17420 PMID: 11279018

Keywords: ZM 336372, supplier, Potent, selective, c-Raf, inhibitors, inhibits, Kinases, ZM336372, AstraZeneca, Raf, Kinase, Raf, Kinase, Tocris Bioscience

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