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Tocris/(<em>S</em>)-3,4-DCPG/1302/10/10 mg

Tocris/(S)-3,4-DCPG/1302/10/10 mg

价格: ¥2388.00 市场价: 3980.00

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货号: 1302/10

品牌: Tocris

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Description: Potent, selective mGlu_8a agonist

Alternative Names: UBP 1109

Chemical Name: (S)-3,4-Dicarboxyphenylglycine

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent, selective mGlu_8a agonist (EC₅₀ = 31 nM). Displays > 100-fold selectivity over mGlu_1-7 and displays little or no activity at NMDA and kainate receptors. Increases c-Fos expression in stress-related brain areas following systemic administration in mice in vivo. Also potent anticonvulsant in mice in vivo. Caged (S)-3,4-DCPG (Cat. No. 3330), (RS)-3,4-DCPG (Cat. No. 1394) and (R)-3,4-DCPG (Cat. No. 1395) also available.

Technical Data

M. Wt	239.18
Formula	C₁₀H₉NO₆
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	201730-11-2
PubChem ID	16062593
InChI Key	IJVMOGKBEVRBPP-ZETCQYMHSA-N
Smiles	N[C@]([H])(C(O)=O)C1=CC(C(O)=O)=C(C(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	phosphate buffered saline	23.92	100
	1eq. HCl	23.92	100
	1eq. NaOH	23.92	100
	water	23.92	100

Preparing Stock Solutions

The following data is based on the product molecular weight 239.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.18 mL	20.9 mL	41.81 mL
5 mM	0.84 mL	4.18 mL	8.36 mL
10 mM	0.42 mL	2.09 mL	4.18 mL
50 mM	0.08 mL	0.42 mL	0.84 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Linden et al (2003) Systemic administration of the potent mGlu8 receptor agonist (S)-3,4-DCPG induces c-Fos in stress-related brain regions in wild-type, but not mGlu8 receptor knockout mice. Neuropharmacology 45 473 PMID: 12907308

Moldrich et al (2001) Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice. Neuropharmacology 40 732 PMID: 11311902

Thomas et al (1997) Dicarboxyphenylglycines antagonize AMPA- but not kainate-induced depolarizations in neonatal rat motoneurones. Eur.J.Pharmacol. 338 111 PMID: 9455991

Thomas et al (2001) (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord. Neuropharmacology 40 311 PMID: 11166323

Keywords: (S)-3,4-DCPG, supplier, Potent, selective, mGlu8a, agonists, Group, III, Receptors, mGlu8R, Glutamate, Metabotropic, UBP1109, UBP, 1109, Glutamate, (Metabotropic), Group, III, Receptors, Glutamate, (Metabotropic), Group, III, Receptors, Tocris Bioscience

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