Anti-TRA-1-60LiveCellStainantibodieshavebeendevelopedforthedetectionofTRA-1-60+cellsdirectlyinculturewithouttheneedforfixation,e.g.,tofacilitatecolonypickingafterreprogrammingortoevaluatepluripotencyofaculturedirectlyinthecellculturedish.
CloneREA157recognizesTRA-1-60antigen,aneuraminidase-resistantcarbohydrateepitopeexpressedonpodocalyxin,whichisatransmembraneglycoprotein.PodocalyxinisamemberoftheCD34-relatedfamilyofsialomucinsandisrecognizedasastemcellandtumour
Marker.TRA-1-60antigenisexpressedonthesurfaceofhumanembryonicstemcells(ESC),embryonicgermcells(EG),andembryoniccarcinomacells(EC).ExpressionofTRA-1-60islostupondifferentiationandthusitcanbeusedtoassessthedifferentiationstageofthecells.TRA-1-60canbedetectedintheserumofpatientswithgermcelltumorswhichcontainanECcomponent.
Additionalinformation:CloneREA157displaysneglig
IBLebindingtoFcreceptors.