CloneREA400recognizesthehuman,mouse,andratcardiactroponinTantigen,aproteinwhichisexclusivelyexpressedathighconcentrationsincardiacmuscleandhasemergedasthepreferredbio
Markerintheuniversaldefinitionofmyocardialinfarction.CardiactroponinTisthetropomyosin-bindingsubunitofthetroponincomplex,whichislocatedonthethinfilamentofstriatedmusclesandregulatesmusclecontractioninresponsetoalterationsinintracellularcalciumionconcentration.MutationsinthecardiactroponinTgenehavebeenassociatedwithfamilialhypertrophiccardiomyopathyaswellaswithrestrictiveanddilatedcardiomyopathy.Transcriptsforthisgeneundergoalternativesplicingthatresultsinmanytissue-specificisoforms.Mutationsofthisgenemaybeassociatedwithmildorabsenthypertrophyandpredominantrestrictivedisease,withahighriskofsuddencardiacdeath.Pluripotentstemcells(PSCs)differentiateintocardiomyocytes positiveforcardiactroponinTandshowing spontaneousrhythmiccontractions.Therefore,PSC-derivedcardiomyocytes haveemergedasapotentialsourceforcardiacregenerationaftermyocardialinfarction.