CloneREA314recognizesthehumanNanogantigen,ahomeoboxtranscriptionfactoralsoknownasEScell-associatedprotein4.Nanogisthoughttobeakeyfactorinmaintainingpluripotency.Itisexpressedinthecentralportionofthemorula,theinnercellmassoftheblastocyst,inembryonicstemcells(ESC)andembryonicgermcells(EGC).TheexpressiondecreaseswithESCdifferentiation.NanogisthoughttofunctioninconcertwithotherfactorssuchasOct-4andSOX2toestablishESCidentity.InhibitionofNanogexpressionhasledtoareductionintum
Origenicityandsuch
invitrocharacteristicsofstemcellsasanchorageindependentgrowthwhereasoverexpressionmayincreasetumorigenicity.