CloneREA326recognizesthehumanC-Cchemokinereceptortype10(CCR10)antigen,amulti-passmembraneproteinwhichisalsoknownasG-proteincoupledreceptor2(GPR2).CCR10isexpressedbyvarioussubsetsofinnate-likeTcellsthatareprogrammedtolocalizetotheskinduringtheirdevelopmentalprocessesinthethymus.CirculatingTcellsmightbeimprintedbyskin-associatedantigen-presentingcellstoexpressCCR10fortheirrecruitmenttotheskinduringthelocalimmuneresponse.Ontheotherhand,IgAantibody–producingBcellsgeneratedinmucosa-associatedlymphoidtissuesexpressCCR10fortheirmigrationandmaintenanceatmucosalsites.CCR10anditsligandschemokinesCCL27andCCL28areuniquelyinvolvedintheepithelialimmunity.CCL27isup-regulatedininflamedskin,whereasCCL28isselectivelyexpressedinintestinalepithelium.Invitro,CCL27−CCR10interactionsmediatethepreferentialmigrationofskin-homingCLA-bearingmemoryTcells.IncreasingevidencealsofoundthatCCR10/ligandsareinvolvedinregulationofotherimmunecellsinepithelialimmunityandarefrequentlyexploitedbyepithelium-localizingor-originatedcancercellsfortheirsurvival,proliferation,andevasionfromimmunesurveillance.
Additionalinformation:CloneREA326displaysneglig
IBLebindingtoFcreceptors.