Capacity:for1×109totalcellsOverview
PositiveselectionordepletionofcellsexpressinghumanLGR5antigen,suchascoloncancerstemcells,orstemcellsfromthesmallintestine,colon,hairfollicle,etc.
Details
Backgroundinformation
LGR5positivecellswerealsoshowntobecrucialduringthedevelopmentandprogressionofcancer.ItwasshownthatLGR5cryptstemcellsarethecells-of-origininintestinalcancerandthatCSCsinhumancolorectalcancercanbeidentifiedandisolatedbasedonLGR5expression.
LGR5associateswithWnt-receptorsandactasR-spondinreceptortherebyplayingacentralroleinthemodulationofWnt/β-cateninsignalinginnormalandneoplasticstemcells
1,2.Initiallydescribedasahighlyspecific
Markerforstemcellsinthesmallintestine,colon,hairfollicle,stomach,andduringkidneydevelopment
3,4,5,6,LGR5positivecellswerealsoshowntobecrucialduringthedevelopmentandprogressionofcancer.ItwasshownthatLGR5
+cryptstemcellsarethecells-of-origininintestinalcancerandthatCSCsinhumancolorectalcancercanbeidentifiedandisolatedbasedonLGR5expression
7,8.
Columns
Forpositiveselection:LS,XS,orauto
MACS®Columns.Fordepletion:LD,CS,D,orautoMACSColumns.
Note:ThisproductisnotsuitableforcellseparationwithanMSColumn.