CloneREA257recognizestheC-Cmotifchemokine3(CCL3)antigenalsoknownasMacrophageinflammatoryprotein1alpha(MIP-1α).CCL3isacytokinebelongingtothemembersoftheβ(CC)subfamilyofchemokines.ItisproducedbyTcells,Bcells,Langerhanscells,neutrophilsandmacrophages.CCL3isinvolvedinactivationandrecruitmentoflymphocytes,monocytes,andgranulocytesduringacuteinflammationandplaysaroleasachemoattractantofmonocytes,Bcells,eosinophilsandcytotoxicTcells.Ithasbeenidentifiedasastemcellinhibitoryfactorthatcaninhibittheproliferationofhematopoieticstemcellsinvitroaswellasinvivo.Moreover,CCL3hasbeenreportedtobeinvolvedinsusceptibilityofHIVinfectionanddiseaseprogressionofAIDS.ThefunctionalreceptorforCCL3hasbeenidentifiedasCCR1andCCR5.
Additionalinformation:CloneREA257displaysneglig
IBLebindingtoFcreceptors.