OligodeoxyribonucleotidescontainingCpGmotifs(CpGODNs)arewidelyusedforactivationofimmunecells,suchashumanPBMCs,murinesplenocytesorisolatedimmunecells,e.g.,BcellsandpDCs.TheyalsoactivatesignallinginTLR9-expressingrecombinantcelllines.
ODN1826stronglyactivatesmurineTLR9.ItisaB-classODNforactivationofBcells,inductionofIl-6secretion,andactivationofNF-kB-signallingpathways.