Capacity:forupto1×109totalcellsOverview
TheAnti-CX3CR1MicroBeadKit,humanhasbeendesignedfortheisolationofCX3CR1+cellsfromperipheralbloodmononuclearcells.
Details
Backgroundinformation
CX3CR1isatransmembranechemokinereceptorwithamolecularmassof40kDa.ItbindsthechemokineCX3CL1,alsoknownasfractalkineorneurotactin.BindingofCX3CR1tothemembrane-boundformoffractalkinepromotescell-celladhesion,whereasthesolubleforminducescellmigrationofCX3CR1-expressingcellssuchasmonocytes,NKcells,Tcells,dendriticcells(DCs),andmacrophagesincludingmicroglia.CX3CR1alsoplaysanimportantroleintheformationoftransepithelialdendritesbyintestinalDCs.Failureinthefractalkine/CX3CR1interactionmaycontributetothedevelopmentofseveralinflammatorydiseasesincludingatherosclerosis,psoriasis,rheumatoidarthritis,andexperimentalautoimmunemyositis.
Applications
PositiveselectionofCX3CR1-positivecells,e.g.,afterdepletingcellsofundesiredlineage.
Columns
MS,LS,orauto
MACS®Columns.