TheAnti-FoxP3antibodyspecificallyrecognizestheforkhead/winged-helixtranscriptionalregulatorFoxP3,alsoknownasforkheadboxP3,scurfin,andJM2.FoxP3isexpressedpredominantlyinregulatoryTcells(Tregs)andisamajor
MarkerandfunctionalregulatorofTregcelldevelopmentandfunction.
1,2MutationsintheFoxP3genearelinkedtotheautoimmunemanifestationsobservedintheScurfymouseandhumanswithimmunedysregulation,polyendocrinopathy,enteropathy,X-linked(IPEX)syndrome.
3,4StudiesinmicehaveshownthatFoxP3-deficientanimalslackTregcells,whereasoverexpressionoftheFoxP3proteinleadstoprofoundimmunesuppression.