TheAnti-PSA-NCAMantibodyrecognizesanepitopeonpolysialicacid(PSA)which,invertebrates,isfoundlinkedtotheextracellulardomainoftheneuralcelladhesionmolecule(NCAM,CD56).¹PSA-NCAM,thehighlypolysialatedformofNCAM,ispredominantlyexpressed
inembryonicandneonatalneuraltissue.²Invitrodifferentiationofhumanandmousepluripotentstemcellsunderdefinedconditionsrevealedthatneuronalprogenitors,e.g.long-termself-renewingneuroepithelial-likestemcells,expressthesurface
MarkerPSA-NCAM.³Magneticallyenriched,invitrogeneratedPSA-NCAMpositiveneuralprogenitorscanbefurtherdifferentiatedintodefinedneuronalsubtypes.